While trying to avoid the cliches of Hollywood romantic comedies, Dylan and Jamie soon discover however that adding the act of sex to their friendship does lead to complications.

Friends with benefits: Jamie (Mila Kunis) is a New York-based executive recruiter who entices Dylan (Justin Timberlake), an art director from Los Angeles, to take a job at the New York office of GQ magazine. Finding that they have much in common, the two become fast friends. Feeling jaded by a number of broken romances, Dylan and Jamie decide that they are ready to quit looking for true love and focus on having fun. However, complications unfold when...